CARDISTM Platform
Discover and optimize ScFv-based CARs to surface-expressed antigens
- Hybrid of phage & proprietary Mammalian Display platforms
- Direct functional selection from cellular library – more & better hits
- Fully human ScFv libraries – lower risk of immunogenicity
- Optimized intracellular signaling domains synergistic to iNKT cells
Bispecific iNKT Cell Engager Platform
Discover and optimize IgG-based iNKT engagers
- Based on proprietary Agenus bispecific antibody platform
- Proprietary iNKT cell engagers arms
- Fully human ScFv libraries – lower risk of immunogenicity
- Direct functional selection – more & better hits
- Designed to work with native and engineered iNKT cells
- Established CMC process and access to Agenus CMC infrastructure