CARDISTM Platform

Discover and optimize ScFv-based CARs to surface-expressed antigens

  • Hybrid of phage & proprietary Mammalian Display platforms
  • Direct functional selection from cellular library – more & better hits
  • Fully human ScFv libraries – lower risk of immunogenicity
  • Optimized intracellular signaling domains synergistic to iNKT cells

 

Bispecific iNKT Cell Engager Platform

Discover and optimize IgG-based iNKT engagers

  • Based on proprietary Agenus bispecific antibody platform
  • Proprietary iNKT cell engagers arms
  • Fully human ScFv libraries – lower risk of immunogenicity
  • Direct functional selection – more & better hits
  • Designed to work with native and engineered iNKT cells
  • Established CMC process and access to Agenus CMC infrastructure